- Researchers used multiple methods to analyze mitochondrial genetic data and identify a mitochondrial microprotein associated with the risk of Alzheimer’s disease.
- They discovered the SHMOOSE microprotein, which appears to have a physiological role in neurodegeneration.
- The mutated version of the SHMOOSE microprotein, found in over 20% of Europeans, is linked to a higher Alzheimer’s disease risk.
- The finding opens new avenues for detecting, preventing, and treating Alzheimer’s disease.
Mitochondria are structures within the cell that convert energy from food into energy the cell can use. Each cell contains hundreds to thousands of mitochondria. Although most DNA is found inside the cell’s nucleus, mitochondria also contain a small amount of DNA, known as mitochondrial DNA.
In the early 2000s, researchers realized that